James Edward Wilcox was born was born on February 14, 1991 in Cairo, Georgia. James first harnessed his skill in football while at high school while playing for Cairo Syrupmakers. He led the Syrupmakers to win the 2008 state championships. He joined Georgia Southern University in 2009 and played as a receiver. He played the safety position in his senior year. He graduated in 2012 and got drafted into NFL in 2013 by signing onto the Dallas Cowboys. He played with the Cowboys until 2016. In 2017 he signed a two-year contract with Tampa Bay Buccaneers but was traded the same year to the Pittsburgh Steelers.